Neurotoxicity following addition of intravenous valproate to lamotrigine therapy.
case_series · Level IV
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- Record sourced from PubMed, PMID 12821749.
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Abstract
Reversible neurotoxic symptoms were observed in three adult patients with absence status epilepticus on lamotrigine (LTG) therapy after administration of an IV bolus followed by oral valproic acid (VPA). Neurotoxicity was likely related to elevated serum LTG levels, as improvement correlated with discontinuing or reducing LTG dosage.
Medical subject headings
- Anticonvulsants
- Confusion
- Epilepsy, Generalized
- Status Epilepticus
- Triazines
- Valproic Acid