Modulation of the onset age in primary dystonia by APOE genotype.
case_control · Level III
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- Record sourced from PubMed, PMID 12821754.
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Abstract
APOE polymorphisms were studied in 200 unrelated patients with primary dystonia as well as 300 age-matched control subjects. Although no difference was found in APOE genotype between the patients with dystonia and the controls, APOE-epsilon4 carriers developed the disease on average approximately 10 years earlier than APOE-epsilon4 noncarriers (p = 0.0012). This suggests that APOE-epsilon4 genotype affects the clinical presentation of primary dystonia.
Medical subject headings
- Apolipoproteins E
- Dystonic Disorders