IgE-mediated allergy to recombinant human insulin in a diabetic.
case_report · Level V
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- Record sourced from PubMed, PMID 12823131.
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Abstract
A 63-year-old nonatopic female suffering from type II diabetes with severe local and systemic immediate-type allergic reactions to injections of different recombinant human insulin products has been reported. Skin testing as well as IgE measurements not only proved immediate-type sensitization to human insulin but also to porcine and bovine insulin which had never been administered and indicated immunological cross-reactivity. Cross-reactivity was proved by an IgE inhibition test. Independent of this reaction, the patient showed IgE-mediated sensitization to protamine.
Medical subject headings
- Diabetes Mellitus, Type 2
- Hypersensitivity, Immediate
- Hypoglycemic Agents
- Insulin