Changes of serum levels of osteocalcin, alkaline phosphatase, IGF-I and IGF-binding protein-3 during fracture healing.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 12832170.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The purpose of this study was to determine the changes in serum markers relating to bone formation during fracture healing. Ten consecutive patients with fractures treated with or without surgery were included. Sera were collected periodically from patients for 80-280 (average 180) days after the fracture. The concentrations of intact osteocalcin, bone-specific alkali phosphatase (ALP), insulin-like growth factor (IGF)-I and IGF-binding protein (IGFBP)-3 in the serum were measured by ELISA. All these serum markers increased or decreased after fracture and fluctuated during fracture healing, however, this pattern differed among the cases. In conclusion, serum markers such as osteocalcin, ALP, IGF-I and IGFBP-3 reflected in part the osteoblastic activity during bone formation.
Medical subject headings
- Alkaline Phosphatase
- Fracture Healing
- Fractures, Bone
- Insulin-Like Growth Factor Binding Protein 3
- Insulin-Like Growth Factor I
- Osteocalcin