Curing metastatic cancer: lessons from testicular germ-cell tumours.

Masters, John R W; Köberle, Beate · Nat Rev Cancer · 2003

review · Level V

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Abstract

Most metastatic cancers are fatal. More than 80% of patients with metastatic testicular germ-cell tumours (TGCTs), however, can be cured using cisplatin-based combination chemotherapy. Why are TGCTs more sensitive to chemotherapeutics than most other tumour types? Answers to this question could lead to new treatments for metastatic cancers.

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