Immunopathogenesis and immunotherapy in AIDS virus infections.

Letvin, Norman L; Walker, Bruce D · Nat Med · 2003

review · Level V

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Abstract

The heterogeneity of HIV and the different human leukocyte antigen (HLA) backgrounds of infected individuals have posed challenges to understanding the pathogenesis of HIV infection. But continuing advances in our knowledge of the role of immune responses in controlling HIV viremia should help to define goals for immune-based therapies and vaccine strategies against AIDS.

Medical subject headings