Extracellular crosstalk: when GDNF meets N-CAM.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 12837237.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
N-CAM has now been identified as a receptor for glial cell line-derived neurotrophic factor (GDNF). This finding solves a long-standing question regarding RET-independent GDNF signaling, and reveals a novel pathway distinct from both GDNF-RET and N-CAM-N-CAM signaling. Functional assays of Schwann cell migration and axon growth of CNS neurons suggest physiological significance for this GDNF-N-CAM pathway.
Medical subject headings
- Cell Communication
- Cell Differentiation
- Growth Cones
- Nerve Growth Factors
- Nervous System
- Neural Cell Adhesion Molecules