The human Y chromosome: rumors of its death have been greatly exaggerated.
review · Level V
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Abstract
Recent papers by David Page and his collaborators present an intriguing new face to the human Y chromosome, including eight massive palindromic arrays, most of which contain multi-copy pairs of testis-specific genes. Sequence pairs within the arms of these palindromic sequences retain a high degree of similarity, suggesting that intrachromosomal gene conversion is frequent, perhaps providing a means of maintaining the integrity of individual members of the array.
Medical subject headings
- Chromosomes, Human, Y
- Eukaryotic Cells
- Gene Expression Regulation, Developmental
- Genes, sry
- Sex Determination Processes