Novel antibody switching defects in human patients.
Level V
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- Record sourced from PubMed, PMID 12840053.
- Also identified by PMC identifier 162297.
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Abstract
Hyper-IgM syndrome (HIGM) is a primary immunodeficiency characterized by normal to elevated serum levels of IgM and low levels or the absence of IgG, IgA, and IgE. A new study AID expression in nonlymphoid cells (see related article on pages 136–142) characterizes HIGM type 4, a previously undocumented defect in antibody gene diversification caused by a selective block in class-switch recombination, providing significant insight towards understanding HIGM immunodeficiencies.
Medical subject headings
- Hypergammaglobulinemia
- Immunoglobulin Class Switching
- Immunoglobulin M
- Recombination, Genetic