Pleasant memories: remembering immune protection while forgetting about graft-versus-host disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 12840055.
- Also identified by PMC identifier 162299.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Graft-versus-host disease (GVHD) represents a major cause of morbidity and mortality following conventional allogeneic hematopoietic stem cell transplantation (HSCT). A study in mice (see related article on pages 101–108) demonstrates that the selective administration of donor memory CD4<sup>+</sup> T cells results in immune reconstitution without GVHD, a result that, if translatable to humans, has important clinical implications for HSCT.
Medical subject headings
- CD4-Positive T-Lymphocytes
- Graft vs Host Disease
- Hematopoietic Stem Cell Transplantation
- Immunologic Memory