Preventing pathological regression of blood vessels.
other · Level V
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- Record sourced from PubMed, PMID 12840056.
- Also identified by PMC identifier 162298.
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Abstract
Oxygen administration to premature infants suppresses retinal VEGF expression and results in the catastrophic vessel loss associated with retinopathy of prematurity. A study investigating the development of the retinal vasculature in mice (see related article on pages 50–57) demonstrates that specific activation of VEGF receptor-1 by placental growth factor-1 protects against oxygen-induced vessel loss without stimulating vascular proliferation and neovascularization.
Medical subject headings
- Endothelial Growth Factors
- Intercellular Signaling Peptides and Proteins
- Lymphokines
- Oxygen
- Pregnancy Proteins
- Retina
- Retinopathy of Prematurity
- Vascular Endothelial Growth Factor Receptor-1