Chlamydia pneumoniae in children with MS: frequency and quantity of intrathecal antibodies.
case_series · Level IV
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Abstract
The authors investigated the frequency and quantity of intrathecal antibody synthesis against Chlamydia pneumoniae and the presence of C pneumoniae antigen in 25 children with MS. C pneumoniae genome was present in two children. In seven children an intrathecal synthesis of C pneumoniae antibodies was detected, representing only a small part of the total intrathecal immunoglobulin G, suggesting that this intrathecal synthesis is part of a polyspecific, oligoclonal immune response.
Medical subject headings
- Antibodies, Bacterial
- Chlamydophila Infections
- Chlamydophila pneumoniae
- Multiple Sclerosis