Osteopontin: a bridge between bone and the immune system.
review · Level V
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- Record sourced from PubMed, PMID 12865402.
- Also identified by PMC identifier 164297.
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Abstract
The molecular mechanisms underlying the putative role of osteopontin in the chronic inflammatory disease rheumatoid arthritis are unclear. A study in a murine model of arthritis now demonstrates that a specific antibody directed against the exposed osteopontin epitope SLAYGLR is capable of preventing inflammatory cell infiltration in arthritic joints.
Medical subject headings
- Sialoglycoproteins