Salicylic acid: an old dog, new tricks, and staphylococcal disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 12865403.
- Also identified by PMC identifier 164295.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Aspirin has been shown to cause a reduction in the virulence of Staphylococcus aureus-associated endocarditis. A new study reveals that salicylic acid, the major metabolite of aspirin, acts at the level of transcription to downregulate the production of fibrinogen, fibronectin, and alpha-hemolysin - virulence factors necessary for bacterial replication in host tissues and, now, potential therapeutic targets.
Medical subject headings
- Anti-Bacterial Agents
- Salicylic Acid
- Staphylococcal Infections