Susceptibility of human T cell leukemia virus type I to nucleoside reverse transcriptase inhibitors.
other · Level V
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Abstract
A single-cycle infection assay with recombinant viral vectors was developed to study human T cell leukemia virus type I (HTLV-I) replication and its inhibition by antiviral agents. The susceptibility of HTLV-I to 6 nucleoside reverse-transcriptase inhibitors was examined. HTLV-I replication was inhibited by tenofovir, abacavir, lamivudine, zalcitabine, stavudine, and zidovudine.
Medical subject headings
- Adenine
- Human T-lymphotropic virus 1
- Organophosphonates
- Reverse Transcriptase Inhibitors