CCR5 mimicry by sulfated human anti-HIV-1 antibodies.
basic_science · Level V
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Abstract
HIV-1 envelope glycoprotein interaction with a principal coreceptor, CCR5, requires sulfated tyrosines on the CCR5 amino terminus. In this issue of Cell, Choe et al. identified tyrosine-sulfated, neutralizing antibodies against HIV-1 that apparently mimic CCR5. The results demonstrate for the first time that a natural posttranslational modification of an antibody can contribute substantially to antigen recognition.
Medical subject headings
- HIV Antibodies
- HIV-1
- Molecular Mimicry
- Receptors, CCR5
- Sulfates