The TNF receptor 1: a split personality complex.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 12887914.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The tumor necrosis factor receptor 1 (TNFR1), a prototypic member of the death receptor family signals both cell survival and apoptosis. In this issue of Cell, report that apoptotic TNFR1 signaling proceeds via the sequential formation of two distinct complexes. Since the first complex can activate survival signals and influence the activity of the second complex, this mechanism provides a checkpoint to control the execution of apoptosis.
Medical subject headings
- Adaptor Proteins, Signal Transducing
- Apoptosis
- Intracellular Signaling Peptides and Proteins
- Proteins
- RNA-Binding Proteins
- Receptors, Tumor Necrosis Factor
- Signal Transduction