A SNARE required for retrograde transport to the endoplasmic reticulum.
basic_science · Level V
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- Record sourced from PubMed, PMID 12893879.
- Also identified by PMC identifier 187870.
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Abstract
SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) are central components of the machinery mediating membrane fusion in all eukaryotic cells. Sequence analysis of the yeast genome revealed a previously uncharacterized SNARE, SNARE-like tail-anchored protein 1 (Slt1). Slt1 is an essential protein localized in the endoplasmic reticulum (ER). It forms a SNARE complex with Sec22 and the ER syntaxin Ufe1. Down-regulation of Slt1 levels leads to improper secretion of proteins normally resident in the ER. We suggest that Slt1 is a component of the SNAREpin required for retrograde traffic to the ER. Based on the previously reported association with Ufe1 and Sec22, Sec20 likely contributes the fourth SNARE to the SNAREpin.
Medical subject headings
- Endoplasmic Reticulum
- Membrane Proteins
- Saccharomyces cerevisiae Proteins
- Vesicular Transport Proteins