Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms.
review · Level V
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Abstract
Recent findings have indicated that dietary calcium, vitamin D and folate can modulate and inhibit colon carcinogenesis. Supporting evidence has been obtained from a wide variety of preclinical experimental studies, epidemiological findings and a few human clinical trials. Important molecular events and cellular actions of these micronutrients that contribute to their tumour-modulating effects are discussed. They include a complex series of signalling events that affect the structural and functional organization of colon cells.
Medical subject headings
- Anticarcinogenic Agents
- Calcium, Dietary
- Colonic Neoplasms
- Folic Acid
- Vitamin D