Statins, inflammation, and sepsis: hypothesis.
Level V
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- Record sourced from PubMed, PMID 12907568.
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Abstract
Sepsis and septic shock are complex inflammatory syndromes. Multiple cellular activation processes are involved, and many humoral cascades are triggered. Statins have anti-inflammatory properties. Our preliminary observations indicate that patients receiving therapy with statins may have a lower incidence of severe sepsis. We hypothesize that statins have a strong protective effect against sepsis by virtue of diverse anti-inflammatory effects that are independent of their lipid-lowering ability.
Medical subject headings
- Acute-Phase Reaction
- Anti-Inflammatory Agents, Non-Steroidal
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Sepsis