Decrypting the role of Cripto in tumorigenesis.
review · Level V
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- Record sourced from PubMed, PMID 12925690.
- Also identified by PMC identifier 171399.
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Abstract
The cell-surface associated molecule Cripto is overexpressed in a wide range of epithelial cancers, yet little is known about potential mechanisms by which Cripto expression might enhance tumorigenesis. A new study reveals that binding of Cripto to the TGF-beta ligand Activin B can block Activin B-mediated suppression of cell proliferation. Furthermore, this study also demonstrates that antibody blockade of Cripto function may prove useful in the inhibition of tumorigenesis.
Medical subject headings
- Epidermal Growth Factor
- Membrane Glycoproteins
- Neoplasm Proteins