Cell proliferation without cyclin E-CDK2.
basic_science · Level V
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- Record sourced from PubMed, PMID 12941268.
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Abstract
In this issue of Cell, Geng et al. report that mice can undergo embryonic development without cyclins E1 and E2. Fibroblasts derived from the double knockout embryos proliferate normally in culture. However, E type cyclins seem essential for endoreplication and exit from quiescence.
Medical subject headings
- CDC2-CDC28 Kinases
- Cell Cycle
- Cyclin E
- Cyclin-Dependent Kinases
- Protein Serine-Threonine Kinases