Evidence for a bone-kidney axis regulating phosphate homeostasis.
Level V
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- Record sourced from PubMed, PMID 12952909.
- Also identified by PMC identifier 182218.
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Abstract
A novel circulation phosphaturic hormone is postulated to regulate systemic phosphate homeostasis. Two new studies reveal that the phosphaturic factor FGF-23 is increased in hypophosphatemic subjects with McCune-Albright syndrome and that secreted frizzled-related protein-4 (sFRP-4), a factor produced by tumors derived from subjects with tumor-induced osteomalacia, also has phosphaturic activity. It remains to be established whether FGF-23 and sFRP-4 represent two distinct phosphatonins or are somehow integrated in a novel phosphate-regulating bone-kidney axis.
Medical subject headings
- Bone and Bones
- Extracellular Matrix Proteins
- Homeostasis
- Kidney
- Phosphates