Expression of lymphocytes and lymphocyte subsets in patients with severe acute respiratory syndrome.
case_series · Level IV
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- Record sourced from PubMed, PMID 12955652.
- Also identified by PMC identifier 7110124.
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Abstract
In a cohort of 38 patients with severe acute respiratory syndrome (SARS), we observed leukopenia in 47% of patients, lymphopenia in 84%, and T lymphopenia in 95%. CD4(+) T lymphocyte levels were reduced in 100% of patients, CD8(+) T lymphocyte levels were reduced in 87%, B lymphocyte levels were reduced in 76%, and natural killer cell levels were reduced in 55%. Our data suggested that these patients' immune systems were impaired during the course of SARS. The absolute counts of lymphocyte subsets demonstrated a clinical significance for patients with SARS.
Medical subject headings
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Lymphocyte Subsets
- Severe Acute Respiratory Syndrome