Alfentanil increases intracranial pressure when intracranial compliance is low.
case_report · Level V
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Abstract
Intracranial pressure increases following the administration of alfentanil 1 mg are reported in five patients with suspected normal pressure hydrocephalus who were undergoing infusion of saline into a lateral ventricle to measure cerebrospinal fluid outflow resistance. The increase in intracranial pressure was accompanied by a fall in mean arterial pressure. These observations show that, when the intracranial compliance is reduced, alfentanil can cause considerable increases in intracranial pressure and decreases in cerebral perfusion pressure.
Medical subject headings
- Alfentanil
- Analgesia
- Hydrocephalus, Normal Pressure
- Intracranial Pressure