15-Deoxy-delta12,14-PGJ2: endogenous PPARgamma ligand or minor eicosanoid degradation product?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 12975467.
- Also identified by PMC identifier 193674.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
15-Deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) affects gene transcription by activating PPARgamma and by covalent addition to transcription factors and signaling molecules, However, it is not known whether the high concentrations of 15d-PGJ2 required for these responses are consistent with physiological levels. A new study suggests that in vivo 15d-PGJ2 levels are actually several orders of magnitude below the levels required to induce many of the biological effects attributed to this molecule.
Medical subject headings
- Immunologic Factors
- Prostaglandin D2
- Receptors, Cytoplasmic and Nuclear
- Transcription Factors