Magnetic resonance spectroscopic measurement of cellular thiol reduction-oxidation state.
basic_science · Level V
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Abstract
Chromatographic and magnetic resonance spectroscopic measurements of thiol reduction-oxidation state in chemically constructed samples show close analytical agreement. This result, coupled with the synthesis of new probe molecules allowing greater sensitivity and lower toxicity, supports the development of an NMR method for non-invasive thiol redox measurement, an important variable in the response of tumors to radiation and chemotherapy.
Medical subject headings
- Amifostine
- Radiation-Protective Agents