Increased calmodulin levels in fibroblasts from progressive systemic sclerosis.
basic_science · Level V
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Abstract
Calmodulin levels in cultured skin fibroblasts from patients with progressive systemic sclerosis (PSS) and healthy controls were measured by their ability to activate cyclic AMP-phosphodiesterase. Calmodulin levels were significantly increased in PSS fibroblasts compared with normal control fibroblasts. The changes in calmodulin content of PSS fibroblasts were also assessed by a radioimmunoassay. These findings suggest that an elevated level of calmodulin may play a role in the pathogenesis of PSS.
Medical subject headings
- Calmodulin
- Fibroblasts
- Scleroderma, Systemic