Mapping antibody binding sites on protein antigens.
basic_science · Level V
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- Record sourced from PubMed, PMID 1313552.
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Abstract
The large surfaces of protein antigens that interact with antibody-combining sites can be determined using deuterium-exchange labelling and two-dimensional 1H nuclear magnetic resonance (NMR). This technique may also be applied to other protein-protein interactions to identify key residues that contribute to the affinity.
Medical subject headings
- Antibodies, Monoclonal
- Antigens
- Binding Sites, Antibody
- Cytochrome c Group
- Proteins