Hemorrhagic cystitis with herpes simplex virus type 2 in the bladder mucosa.

Nguyen, M L; Borochovitz, D; Thomas, G; McClure, T; Ruben, F L · Clin Infect Dis · 1992

case_report · Level V

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Abstract

A 67-year-old woman who had underlying rheumatoid arthritis and diabetes mellitus had an 8-year history of recurrent hemorrhagic cystitis. During her most recent episode of cystitis, a specimen of urine yielded herpes simplex virus type 2 in culture. A biopsy of the bladder mucosa revealed intranuclear inclusions in multinucleated and mononuclear giant cells that were positive for herpes simplex virus type 2 by immunoperoxidase staining. She had no evidence of infection with herpes simplex virus outside her bladder.

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