Replication of human herpesvirus 6 in epithelial cells in vitro.

Simmons, A; Demmrich, Y; La Vista, A; Smith, K · J Infect Dis · 1992

basic_science · Level V

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Abstract

Mink lung epithelial (NBL-7) cells were shown to be permissive for human herpesvirus 6 (HHV-6) by four independent methods of analysis: detection of infectious virus, viral antigens, viral DNA sequences, and herpesvirus particles. Infection was serially passaged, with minimal cytopathology, for several months demonstrating for the first time that a cell of epithelial origin can support HHV-6 replication.

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