Animal models of varicella.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 1320650.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Varicella-zoster virus (VZV) is highly species-specific and has been demonstrated to naturally infect only humans and great apes. Simian varicella, a group of antigenically related agents distinct from VZV, infects cercopithecoids producing severe varicella-like disease but does not infect humanoids. Seroconversion following inoculation of VZV in small laboratory animals has been demonstrated in the rat, rabbit, and guinea pig; however, animal-to-animal spread, viremia, and exanthem have been demonstrated only in guinea pigs. Both humoral and cellular immune responses to VZV infection have also been examined in the guinea pig model. Ocular infection with VZV has been explored in both the guinea pig and rabbit. Animal models of VZV persistence have been elusive although persistence may be established in the rat.
Medical subject headings
- Chickenpox
- Disease Models, Animal