Botulinum toxin therapy: distant effects on neuromuscular transmission and autonomic nervous system.
case_series · Level IV
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- Record sourced from PubMed, PMID 1328540.
- Also identified by PMC identifier 1015114.
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Abstract
To evaluate distant effects of botulinum toxin, single fibre electromyography on the extensor digitorum communis muscle and six tests of cardiovascular reflexes were performed in five patients injected with BoTox (Oculinum(R) 20-130 units) for craniocervical dystonia and hemifacial spasm. Patients underwent two sessions of treatment and the second time the dosage was doubled. Botulinum toxin injection induced an increase of mean jitter value above normal limits in all cases. An increase of fibre density was recorded six weeks after the treatment. Cardiovascular reflexes showed mild abnormalities in four patients. The data confirm distant effects of botulinum toxin on neuromuscular transmission and on autonomic function.
Medical subject headings
- Autonomic Nervous System
- Blepharospasm
- Botulinum Toxins
- Facial Muscles
- Neuromuscular Junction
- Spasm
- Synaptic Transmission
- Torticollis