Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents.
basic_science · Level V
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Abstract
Miniature excitatory synaptic currents were recorded from CA1 pyramidal cells in hippocampal slices to study the site of the persistent change in synaptic efficacy during long-term potentiation. Induction of long-term potentiation produced a large increase in the amplitude of these currents. Such a change in amplitude suggests an increase in postsynaptic transmitter sensitivity.
Medical subject headings
- Hippocampus
- N-Methylaspartate
- Pyramidal Tracts
- Synapses