Production and characterization of a murine/human chimeric anti-idiotype antibody that mimics ganglioside.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 1348012.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The VL and VH from a murine anti-idiotypic antibody that mimics ganglioside have been cloned, sequenced, and expressed as a chimeric mouse/human IgG1 antibody. The chimeric antibody retained a binding specificity indistinguishable from the original murine antibody. The VH was a member of Vgam 3.8 family. The sequences are discussed in terms of ways in which proteins may mimic ganglioside epitopes.
Medical subject headings
- Antibodies, Anti-Idiotypic
- Gangliosides
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains