Asymmetric distribution of oncogene products at mitosis.
basic_science · Level V
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- Record sourced from PubMed, PMID 1350677.
- Also identified by PMC identifier 49187.
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Abstract
Computer-assisted image analysis was used to demonstrate in exponentially proliferating human tumor cells the uneven postmitotic apportionment of several oncogene-encoded proteins (ras p21; erbB-2 p185; fos p55; myc p62). This observation may provide the explanation for the high degree of heterogeneity of postmitotic cells and the asynchrony in cell cycle traverse of cultured cells.
Medical subject headings
- Cell Compartmentation
- Mitosis
- Proto-Oncogene Proteins