Detection of serum IgM antibodies to glomerular basement membrane in two cases of nephropathia epidemica.
case_report · Level V
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Abstract
We report two serologically verified cases of nephropathia epidemica (NE) who developed high serum levels of non-Goodpasture IgM antibodies against glomerular basement membrane (anti GBM) in the acute phase of the disease. Moreover, in one of the patients a renal biopsy showed granular deposits of complement factor 3 along the glomerular capillary walls. The possible pathogenic significance of these findings is discussed.
Medical subject headings
- Autoantibodies
- Hemorrhagic Fever with Renal Syndrome
- Immunoglobulin M
- Kidney Glomerulus