Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice.
basic_science · Level V
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- Record sourced from PubMed, PMID 1360667.
- Also identified by PMC identifier 50546.
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Abstract
Injection of mice transgenic for a class I major histocompatibility complex-restricted T-cell receptor with a soluble peptide antigen from influenza virus nucleoprotein results in clonal depletion of double-positive immature thymocytes in the thymus and activation of mature T cells in the periphery, accompanied by a transient up-regulation of the T-cell receptor and CD3 and CD8 coreceptor molecules.
Medical subject headings
- Histocompatibility Antigens Class I
- Nucleoproteins
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocyte Subsets
- Thymus Gland
- Viral Core Proteins