Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.
case_control · Level III
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- Record sourced from PubMed, PMID 1362221.
- Also identified by PMC identifier 1016201.
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Abstract
Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).
Medical subject headings
- Chromosomes, Human, Pair 3
- Receptors, Dopamine
- Receptors, Dopamine D2
- Schizophrenia