Dynamic release of Cdc34 from SCF. the hand that rocks the cradle.
review · Level V
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Abstract
Polyubiquitylation is a complex but poorly understood biochemical reaction catalyzed by E3 ubiquitin ligases. In this issue of Cell, Deffenbaugh et al. provide experimental support for a model in which the dynamic release of the ubiquitin-charged E2 Cdc34 from its primary binding site within the rigid cradle-like SCF E3 complex allows for unexpected spatial flexibility to assemble a polyubiquitin chain.
Medical subject headings
- Ligases
- Stem Cell Factor
- Ubiquitin
- Ubiquitin-Protein Ligase Complexes