Secrets of a secretase: N-cadherin proteolysis regulates CBP function.
basic_science · Level V
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Abstract
Presenilin (PS-1) is part of the protease gamma-secretase that cleaves the membrane proteins APP and Notch. In this issue of Cell, Marambaud et al. report that PS-1 cleaves the cell adhesion molecule N-cadherin, releasing a C-terminal fragment that promotes degradation of the transcriptional coactivator CBP. Mutations in PS-1 associated with Alzheimer's disease interfere with CBP proteolysis, leading to abnormal transcription.
Medical subject headings
- Cadherins
- Carrier Proteins