Granulocyte colony stimulating factor in the management of chronic neutropenia.
case_report · Level V
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Abstract
OBJECTIVE: To report two cases of chronic neutropenic states successfully treated with granulocyte colony stimulating factor (G-CSF). CLINICAL FEATURES: A 23-year-old man with severe congenital cyclic neutropenia causing lifelong recurrent infections and consequent debilitation presented with intractable infected leg ulcers. A 56-year-old man with acquired idiopathic neutropenia presented with severe perianal infection and sepsis. INTERVENTION AND OUTCOME: Both patients were successfully treated with recombinant G-CSF. CONCLUSION: G-CSF is an agent with major clinical potential for the therapy of primary neutropenic states.