Cyclin D1 messenger RNA is inducible by platelet-derived growth factor in cultured fibroblasts.
basic_science · Level V
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Abstract
In fibroblasts in culture, the levels of cyclin D1 mRNA are growth regulated. In mouse and in human fibroblasts, both serum and platelet-derived growth factor increase cyclin D1 mRNA levels with similar kinetics of induction. Insulin-like growth factor 1 by itself does not induce cyclin D1 expression, and an antisense oligodeoxynucleotide to the insulin-like growth factor 1 receptor RNA does not affect the growth-regulated levels of cyclin D1 mRNA.
Medical subject headings
- Carrier Proteins
- Cyclins
- Fibroblasts
- Leukemia, Promyelocytic, Acute
- Platelet-Derived Growth Factor
- RNA, Messenger