A recombination event that redefines the Huntington disease region.
basic_science · Level V
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- Record sourced from PubMed, PMID 1386495.
- Also identified by PMC identifier 1682687.
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Abstract
We report both a recombination event that places the Huntington disease gene proximal to the marker D4S98 and an extended linkage-disequilibrium study that uses this marker and confirms the existence of disequilibrium between it and the HD locus. We also report the cloning of other sequences in the region around D4S98, including a new polymorphic marker R10 and conserved sequences that identify a gene in the region of interest.
Medical subject headings
- Chromosomes, Human, Pair 4
- Huntington Disease
- Recombination, Genetic