Serotonergic dysfunction in depression associated with Parkinson's disease.
case_report · Level V
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- Record sourced from PubMed, PMID 1387464.
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Abstract
A 55-year-old man presented with a 5-year history of Parkinson's disease and a 6-month history of major depression. The patient's depressive symptoms responded to treatment with fluvoxamine, a selective and potent serotonin reuptake inhibitor. Tryptophan depletion testing, which acutely lowers central serotonin levels, caused a brief exacerbation of the depressive illness, which resolved upon tryptophan repletion. Serotonergic dysfunction may be an etiologic factor in depression that occurs in Parkinson's disease.
Medical subject headings
- Depressive Disorder
- Parkinson Disease
- Serotonin