Implantation of p(HEMA)-collagen composite into bone.
basic_science · Level V
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- Record sourced from PubMed, PMID 1391411.
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Abstract
The replacement of bone defects is very important in clinical practice. This study compares biological properties of poly(2-hydroxyethyl methacrylate)-collagen composite with those exhibited by pure p(HEMA), an insoluble fraction of calf skin collagen (ISC-40) and demineralized bone matrix after implantation into pig or dog femurs. The levels of biodegradation or destruction of implants and healing of bone defects were studied using X-ray photography, histology and enzyme histochemistry. The results indicated a significant effect of collagen on biological destruction of the p(HEMA)-composite implants; even a minute amount of collagen influences this process dramatically. A stimulatory action of collagen on new bone formation may be of importance in bone defect healing.
Medical subject headings
- Biocompatible Materials
- Bone and Bones
- Collagen
- Polyhydroxyethyl Methacrylate
- Prostheses and Implants