Increased secretion of interleukin-6 in malignant mesothelioma cells from a patient with marked thrombocytosis.
case_report · Level V
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Abstract
A high prevalence of thrombocytosis in malignant mesothelioma has been reported, although its pathogenesis remains unknown. The case of a patient with marked thrombocytosis in peritoneal malignant mesothelioma is reported. To investigate the cytokines responsible for thrombocytosis in this patient, enzyme-linked immunosorbent assay and immunohistochemical analysis were used. Tumor cells produced large amounts of interleukin-6 (IL-6) and small amounts of granulocyte macrophage colony stimulating factor (GM-CSF) and monocyte colony stimulating factor (M-CSF). Immunocytochemical staining of tumor cells showed strong positivity for IL-6. These results indicated that persistent secretion of IL-6 promoted thrombogenesis in this patient.
Medical subject headings
- Interleukin-6
- Mesothelioma
- Peritoneal Neoplasms
- Thrombocytosis