An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains.
basic_science · Level V
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Abstract
The monoclonal antibody OVTL3 has a highly restricted reactivity with ovarian carcinomas and defines a surface glycoprotein, OA3, which has been used for immunotargeting. To understand why OA3 is found on ovarian tumors we isolated a complementary DNA by expression cloning. The clone encodes a 323-amino acid protein with 5 putative membrane spanning domains, reminiscent of a membrane receptor or channel, but of a new type with little or no sequence similarity with these families of proteins. Interestingly, the OA3 sequence is highly related to a vaccinia virus encoded protein (VA38) and its extracellular domain is a member of the immunoglobulin V region superfamily.
Medical subject headings
- Antigens, Neoplasm
- Biomarkers, Tumor
- Immunoglobulin Variable Region
- Membrane Proteins
- Ovarian Neoplasms
- Vaccinia virus