Alterations in bile following urinary intestinal diversion.

Abstract

In order to determine whether alterations in bile occur which make it more lithogenic when intestinal segments are interposed in the urinary tract, 42 female Sprague-Dawley rats had intestinal and urointestinal manipulations followed by analysis of bile constituents. Timed collections were obtained from the common bile duct which were analyzed for bile acids, phospholipids, cholesterol, bilirubin, volume, osmolality, pH, calcium, chloride, sodium, and potassium. Changes in bile constituents were identified following urinary diversion which were specific for the type of diversion and the segment of bowel used, but they were not of sufficient degree to cause significant changes in the lithogenicity of bile. This correlates well with the lack of clinical findings of cholelithiasis in children with urinary intestinal diversion.