Sotalol-induced torsade de pointes: management with magnesium infusion.
case_report · Level V
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- Record sourced from PubMed, PMID 1409197.
- Also identified by PMC identifier 2399266.
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Abstract
A 69 year old woman was treated with sotalol (320 mg daily) for intermittent atrial fibrillation. Sotalol was initially well tolerated and reversion to sinus rhythm with sinus bradycardia occurred 4 weeks after initiation of therapy. Shortly thereafter, the patient developed recurrent syncope due to torsade de pointes. This was treated successfully with intravenous magnesium infusion and withdrawal of sotalol. Subsequently, the atrial fibrillation was adequately managed using amiodarone, with no recurrence of torsade de pointes. Development of bradycardia associated with reversion to sinus rhythm represents a potential cause of 'late' pro-arrhythmic effects of sotalol.
Medical subject headings
- Atrial Fibrillation
- Sotalol
- Torsades de Pointes